Cellular Metabolism

Cellular Metabolism

MCB3410

These are notes from Tymoczko, Berg, and Stryer's book "Biochemistry: A Short Course." Hope this helps. This by no means justifies that I am an expert at the material, and by no means replaces the text book or the course.

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ISBN:0716758407. Published by Pearson Education.

Notes

Chapter 1: Biochemistry and the Unity of Life

Chapter 1

Chapter 2: Water, Weak Bonds, and the Generation of Order Out of Chaos

Chapter 2 Water

Chapter 3: Amino Acids

Chapter 3&4 Proteins

Chapter 4: Protein Three Dimensional Structure

Chapter 3&4 Protiens

Chapter 5: Basic Concepts of Enzyme Action

Chapter 5&6 Chapter 5 Supplemental Enzymes

Chapter 6: Kinetics and Regulation

Chapter 5&6 Chapter 6&7 Enzymes

Chapter 7: Mechanisms and Inhibitors

Chapter 6&7 Enzymes

Chapter 8: Hemoglobin, an Allosteric Protein

Chapter 8 Notes - no lecture for this

Chapter 9: Carbohydrates

Carbohydrates - no lecture for this see Biomolecules

Chapter 10: Lipids

Lipids - no lecture for this see Biomolecules

Chapter 11: Membrane Structre and Function

Cell Membrane - no lecture for this, book notes

Chapter 12: Signal Transduction Pathways

Chapter 12 Signal Transduction

Chapter 13: Basic Principles and Practices

Chapter 13&14

Chapter 14: Metabolism: Basic Concepts and Design

Chapter 13&14 Cell Metabolism

Chapter 15: Glycolysis

Chapter 15&16 Glycolysis

Chapter 16: Gluconeogenesis

Chapter 15&16 Gluconeogenesis

Chapter 17: Preparation for the TCA Cycle

Chapter 17&18 Citric Acid Cycle

Chapter 18: Harvesting Electrons from the TCA Cycle

Chapter 17&18 Citric Acid Cycle

Chapter 19: The Electron Transport Chain

Chapter 19&20 Electron Transport Chain

Chapter 20: The Proton Motive Force

Chapter 19&20 Electron Transport Chain

Chapter 21: The Light Reactions

NOT covered

Chapter 22: The Calvin Cycle

NOT covered

Chapter 23: Glycogen Degradation

Chapter 23&24 Glycogen

Chapter 24: Glycogen Synthesis

Chapter 23&24 Glycogen, Gluconeogenesis

Chapter 25: The Pentose Phosphate Pathway

Chapter 25 Pentose Phosphate Pathway

Chapter 26: Fatty Acid Degradation

Chapter 26&27

Chapter 27: Fatty Acid Synthesis

Chapter 26&27

Chapter 28: Lipid Synthesis: Storage Lipids, Phospholipids and Cholesterol

Chapter 28

Chapter 29: Amino Acid Synthesis

Chapter 29&30

Chapter 30: Nucleotide Metabolism

Chapter 29&30

Chapter 31: Amino Acid Degradation and the Urea Cycle

Chapter 31

Chapter 32: The Structure of Informational Macromolecules: DNA and RNA

Genetics - sorry comming soon

Chapter 33: DNA Replication

Genetics - sorry comming soon

Chapter 34: DNA Repair and Recombination

Genetics - sorry comming soon

Chapter 35: RNA Synthesis and Regulation in Prokaryotes

Genetics - sorry comming soon

Chapter 36: Gene Expression in Eukaryotes

Genetics - sorry comming soon

Chapter 37: RNA Processing in Eukaryotes

Genetics - sorry comming soon

Chapter 38: The Genetic Code

Genetics - sorry comming soon

Chapter 39: The Mechism of Protein Synthesis

Genetics - sorry comming soon

Devlin CH21: Iron and Heme Synthesis

Devlin - Iron

Devlin CH24: Exotics - Eye and Blood Coagulation

Devlin - Exotics

Supplemental

• Text Book Google Books Incomplete

Personal Mental Notes:

• Cysteine is OXIDIZED to produce sulfide bonds
  • Why, oxidation is a loss of elelctrons
  • Cysteine is AAbackbone-CH2-S-H
    • Meaning that when the two Cysteines get in close proximity, they will both lose an electron to form a disulfide bond
• Mitochondria PRODUCE HEME
• 7TM has a biological function of CELL DIFFERENTIATION
• Triose phosphate isomerase is REVERSIBLE
• Pep hydrolysis - last 1/3 of glycolysis
• Cholera - what is interaction in Gprotiens
• GLC in liver - specifics
• Bicarbonate
• dG = dG' + RTln[EQ] where RT ~ .616
• Argininosuccinate Synthetase Def = BENIGN
  • Even though it is a N metabolism ENZ and that disfuntions in N metabolism produce toxic effects, this is one a few exceptions
    • While it does create a step that is part of the Urea Cycle, (Argininosuccinate) to make arginine, Arginine is an AA in the cytosol (received from diet) and not a necessary to be synthesized via the cycle when Arg can be brought in from the extracellular environment